The NFL Week 7 schedule features an impressive slate of matchups across the league, highlighted by several key games that could help shape the NFL playoff picture. The Los Angeles Chargers (-1.5, 48.5) host the Indianapolis Colts in a matchup between the teams that top the early AFC standings, and the Dallas Cowboys (+1.5, 54.5) host the Washington Commanders in an NFC East rivalry game that is expected to Have high scores. Sunday’s slate concludes with the Atlanta Falcons taking on the San Francisco 49ers (-1.5, 47) in an NFC showdown. Finally, “Monday Night Football” includes a two-game slate with Buccaneers vs. Lions (-5.5, 52.5) and Texans vs. Seahawks (-3.5, 41.5).
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The model, which simulates every NFL game 10,000 times, is priced at more than $7,000 for $100 top-ranked players. NFL picks Since its beginning. The model is at 42-25 on top-rated picks dating back to 2024. Anyone who follows NFL betting picks at sportsbooks and betting sites would have seen strong returns.
Now that the simulation model has had a chance to digest the Week 7 NFL odds, it has limited its betting selections to form a 5-leg NFL betting that could pay over $21,000 to a $10 bettor. You can just see the picks and full payouts by heading over to SportsLine.
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Top NFL Week 7 Picks.
In Week 7, one of the model’s picks is to back the Broncos at the swing line of -9.5 against the Giants, a bet that returns +118. The standard spread is Colts -7, but the model has spotted an opportunity for expansion here.
The Broncos are expected to win 75% of the time, and the model’s margin of victory is 10 points, leaving plenty of room to play alternate lines. The Broncos were one of the best teams in the AFC in 2025, and they may have the best defense in the entire NFL. Denver is coming off a 13-11 win over the New York Jets in London, and enters this matchup on a three-game winning streak.
The Broncos are off to a 4-2 start, their best opener since 2016. Quarterback Bo Nix leads the way with 1,277 yards and nine touchdowns, while JK Dobbins has 442 yards and four scores. On defense, Nick Bonito leads the team with eight sacks, and the team is bolstered by standout play from Zach Allen and NFL Defensive Player of the Year Patrick Surtain II. See the rest of the NFL Week 7 picks here.
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How to Choose an NFL Investing for $21,000+ Payout
The investment also includes four additional picks from SportsLine’s computer model, including a first down scorer prop bet that returns +900. You can only see the full picks and payouts on SportsLine.
What are the best Week 7 NFL picks that can be combined into an investment that will yield over $21,000 on just a $10 bet? What is the best bet on a first down scorer who returns +900? Visit SportsLine now to see the top NFL picks for Week 7 from SportsLine’s proven model that can be combined for an investment that pays over $21,000And find out.