Sugars change the microbium intestine, disrupt the activity of T cells, and reduce the effectiveness of immunotherapy.
SUCRALOSE is a artificial locality widely used for people who aim to cut calories or control blood sugar, but new research from the University of Pittsburgh and the APMC Hillman Cancer Center may not be suitable for patients who receive immunotherapy.
The study, which was recently published in the magazine Cancer detection By the American Association for Cancer Research, it stated that individuals with lung cancer from the non -small cells who consumed large quantities of sugar have responded less effectively for immunotherapy and had lower survival rates compared to those who consume a little sweetener.
It is worth noting, in mouse experiences, nutritional supplements that have increased the levels of amino sour Arginine has faced the negative effect of the sugar on immunotherapy, pointing to a possible strategy that can be explored in clinical trials.
Arginine as a possible solution
“It is easy to say,” stop drinking diet soda, “said the lead author Abeokkri, assistant professor at the House of Immunology Department and UPMC Hillman, but when patients are treated for cancer, they are already dealing with enough, so their request to change their diet may not be significantly realistic.” “We need to meet patients where they are. This is so exciting that Arginine supplements can be a simple way to face the negative effects of almond sugar on immunotherapy.”
A great author Diwakar Davar, associate professor of medicine at Beit, a medical oncologist and a blood specialist at UPMC Hillman, with Overracre and their team to show mouse models that the harmful effects of sugar stems from the disorders in the bacteria of the intestine.
The local changed the microbium microbium mouse makeup, and increased bacteria Class That shatters Arginine. This shift led to low levels of arginine in the blood, the tumor and stool environment.
Immune checkpoint inhibitors such as PD1 are promoting T -cell activity, which allows these immune cells to attack cancer more effectively. Arginin plays an important role in supporting T cell function, especially in the context of cancer.
“When arginine levels were exhausted due to the transformations driven by sugar in the microbium, the cells cannot work properly,” said Overracre. “As a result, immunotherapy was not effective in mice feeding sugar.”
In mouse models of glandular cancer and skin cancer, diets that contain sugar weaken the anti -PD1 treatment, which leads to larger tumors and shorter survival. However, when the mice that feed the sugar are arginine or sterolin (which the body turns into arginine), the effectiveness of immunotherapy was restored.
Human data and future experiences
To assess the importance of these results for humans, researchers in 132 patients with advanced skin cancer or uneven lung cancer who have received anti -PD1 treatment on its own or in combination with chemotherapy. Patients filled the questionnaires of the history of the detailed diet that included questions about the number of times they consumed artificial sweeteners in coffee, tea and diet soda.
Davar said: “We have found that sugar has hindered the effectiveness of immune treatments through a group of types of cancer, stages and treatment methods.” “These observations increase the possibility of designing Pruyotics, such as targeted nutrient supplements for patients who consume high levels of sugar.”
The researchers hope to launch a clinical trial that realizes whether the srulin supplements-which enhance the levels of Arginine more than arginine itself-affect the microbiomeum of the intestine and the anti-tumor immune response in patients.
They are also interested in looking at how other sugar alternatives, such as aspartame, sugar, Xylitol, and Stevia, affect the immune system and respond to immunotherapy.
Reference: “SUCARLOSE Canuction Canucer Consumption of Immunotherapy by disrupting lime.” Written by Christine M. Mourder, Madison Najin, Drew N. And I will appear, Zakaria Larbi. Dahmani, Ansen BP. Burr, Bingxian XIE, Michael Morikone, Hector Nieves-roc, William G. Gunn, Drew E. Hurd, Hong Wang, Steven J. Cancer detection.
Second: 10.1158/2159-8290.cd-25-0247
This research has been supported by National Institutes of Health (DP2AI177967, S10D023402, S10D032141, R01CA206517, R01AI138504, T32GM008208 and U01 Ca271407 and R01 Ca257265 and U01 Ca268806 and P50 Ca27486) Cancer Research portal (G-22-800).
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