The primitive alternative in ampd1 of its enzymatic activity reduces 25 % in the proteins produced by the laboratory and by up to 80 % in the genetic engineering muscles; The alternative is found in all sequential primitive species, but is absent in all other types. The modern human genes gathering entered the successive about 50,000 years ago. As a result, up to 8 % of the current Europeans carry it.
tickle And others. It has shown that the inherited genetic alternative to primitive humans weakens the main enzyme function involved in muscle performance. Credit Image: Holgger Newman / Neanderthal Museum.
The enzyme APD1 plays a major role in the production of muscle energy and the natural muscle function.
The loss of his activity due to genetic mutations is the most common cause of allegiance muscle illness in Europeans, as it occurs at a frequency of 9 to 14 %.
In a new study, Dr. Dominic Makak of the Max Planck Institute for Evolutionary Anthropology and his old primitive DNA colleagues compared to modern human genres.
They found that all primitive humans carry an ampd1 variable absent in other types.
The enzymes produced by the laboratory with this alternative showed a 25 % decrease in the APD1 activity.
When inserting it into genetically engineered mice, the reduction reached 80 % in muscle tissue, which weakens the function of the enzyme.
The researchers also revealed that contemporary humans inherited this alternative through interference with primitive humans, who inhabited Europe and West Asia before confronting contemporary humans about 50,000 years ago.
Today, individuals of non-African origin carry approximately 1-2 % of primitive DNA.
The primitive ampd1 variable is performed by 2-8 % of Europeans today, indicating that it is generally tolerance.
“Most of the individuals who carry the alternative do not face major health problems,” said Dr. Makak.
“However, the enzyme seems to play an important role in sports performance.”
An analysis of more than a thousand elite athletes across various sports revealed that individuals carrying ampd1 are not functional to become athletes at the highest level.
Dr. Makak said: “The broken ampd1 enzyme, the possibility of access to sports performance is reduced by half,” said Dr. Makak.
Although APD1 activity seems to be of moderate importance only in contemporary Western societies, it is important in light of extremist material conditions, such as those that athletes suffer.
Scientists emphasize the importance of studying genetic variables in their physiological and developmental contexts in order to understand their biological effects.
“It is possible that cultural and technological progress in both modern humans and exiles reduced the need to perform severe muscles,” said Dr. Hugo Zeberg, a researcher at the Max Planck Institute for Evolutionary Anthropology and the Carolinska Institute.
“Understanding how ancient genetic variables affect human physiology today can provide valuable visions in health, performance and genetic diversity.”
the Results It was published on July 10, 2025 in the magazine Nature Communications.
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D. Makak And others. 2025. DEAMINASE muscle activity was less in obesity than contemporary people. Nat Common 16, 6371; Second: 10.1038/S41467-025-61605-4