ILast year, the doctors performed the transplants in the manufacture of history, and they put two genetically modified pigs and Pork In patients. Now, a group of doctors and scientists in China mentioned that they did the same with the pork liver.
in A study published in natureThe collection describes the transplant of the pork edited genes in a comfortable patient in the brain. At the request of the patient’s family, the study was completed after 10 days and the pork liver was removed. The patient’s original liver was not removed, so the experiment was a way to test whether the pork liver could complete the failed liver function for patients waiting for a transplant.
“The liver of the cultivated pig successfully secreted the bile in the production of albumin derived from the liver, and we believe this is a great achievement,” said Dr. Lin Wang, a surgeon at the Chiking Hospital, the Fourth Military Medical University and a senior newspaper. “This means that the pork liver can remain with the original liver in a person – and will provide additional support to the affected liver, perhaps, in the future.”
Pigs are promising sources for organs, but the human immune system rejects the tissue of cultivated pigs. Scientists were wandering about this by modifying the pigs that provide organs. The donor liver came in this case from a pig that received six adjustments to certain genes in order to remove the main pig proteins that would have led to rejection; Liberation technology also added genes that made the liver look more humane for immune cells.
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Earlier this year, a surgical team at the University of Pennsylvania I mentioned A comfortable patient in the brain connects with a pork edited genes that remain outside the patient’s body, but the results have not been published in a journal reviewed by the peer. In the Chinese case, Wang and his team cultivated the liver in the patient, linking the main blood vessels to monitor the quality of the production of major vehicles such as bile and albumin.
Wang said that blood flow to and from the liver, as well as the measures of things like the production of bile and albumin, was encouraging, even if not all functions were sufficient enough to completely imitate the human liver. There were changes in platelets and coagulation functions shortly after the transplant, but it seems that those that were resolved after a few days. The pork liver began to produce bile after two hours of transplant, and the levels of albumin began to increase the process. When the team analyzed the liver after removing it after 10 days, there were no signs of immune rejection, “they wrote in the paper.
The transplant came after about a decade of previous studies and planting by Wang and his team from the genetic modified organs from pigs to monkeys, including the heart of the pig, kidneys, cornea and bones. The group also performed a leather transplant using genetic pig skin in a person with severe burns.
“The liver has been a challenge to plant with anything other than the other human liver, because the organ performs many complex functions. He said: “The heart acts as a pump to pump blood into the whole human body, and the main function of the college is urine production.” However, the liver has many functions. It has digestion functions, to make cytokines [that regulate the immune system]And the production of albumin. This is a great achievement because it is the first time that we can reveal whether the liver -derived liver can work well in the human body or can replace the human liver successfully in the future. “
Wang said that the team also implanted the liver that the pigs freed into a patient with a patient to the brain after taking out the patient’s liver, and is currently watching the quality of work on its own. He hopes to perform additional transplants, both of which mimic the current study in which the pork liver works alongside the patient’s liver, as well as replacing the liver of patients entirely, next year.