Kind of Paenibacillus Bacteria have a strong antibacterial activity against some pathogenic bacteria such as Show the cold.Credit: Clouds Hill Imaging Ltd/Science Photo Library
Researchers have discovered a new antibiotic molecule targeting a wide range of pathogenic bacteria-even strains resistant to commercial drugs-which is not toxic to human cells1.
The molecule is found in the soil samples collected from the laboratory technician park. “The discovery shows that” there are terribly interesting things in the sight of the horizon, “says Kim Lewis, a microbiologist at the University of North Eston in Boston, Massachusetts, who did not participate in the research.
The last molecule targets a protein manufacturer in bacteria, ribosome, in a way that other antibiotic drugs do not do. Lewis adds that the ribosome is an attractive goal for antibiotics because bacteria do not develop easily resistant to drugs targeting the structure.
Searching for new antibiotics is necessary because bacteria gain resistance to existing drugs with continuous use. In 2021, the bacterial resistance of antimicrobial drugs was associated with 1.1 million deaths worldwide, a number that could exceed 1.9 million by 2050.
“The antibiotic resistance crisis is an existential threat to medicine,” says Jerry Wright, a chemical biologist at McMaster University in Hamilton, Canada, and a co -author of the study. nature today.
A clear garden bacteria
Wright and his colleagues set out to find the microbes that have previously developed unknown tricks to kill pathogens. They collected soil samples in Petri dishes with average growth and store them for a year. Then the researchers revealed the microbes from these samples to Show the coldCommon intestinal bacteria that can cause serious illness.
One sample showed an anti -bacterial activity – by a gender type Paenibacillus.
Other tours of examination, genome sequence and structural analysis revealed that bacteria produce a molecule belonging to a group of peptides that make up a Laso -shaped knot. These peptides are famous as strong and may survive their digestion. “It is a pleasant, really, and incredibly integrated structure,” says Wright.
The molecule, which is called the researchers, is associated with ribosome, and also the transfer of RNA, which supplies ribosome using the building blocks of the amino acids that it needs to connect peptide chains. By doing this, it prevents reading properly, as well as spoiling the symbol, and the output is mixed. Ultimately, this means that the ribosome produces incorrect peptides, some of which may end as toxic bacteria and kill them, Lewis says. He adds that Laureosidin uses a different way to work for other antibiotics, as pathogens have not already developed resistance to it.