Ultra-high-throughput mapping of genetic design space
de Boer, C. G. et al. Deciphering eukaryotic gene-regulatory logic with 100 million random promoters. Nat. Biotechnol. 38, 56–65 (2020). ...
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Dominant contribution of Asgard archaea to eukaryogenesis
Database curation For prokaryotes, 75 million sequences were curated from 47,545 fully sequenced prokaryotic genomes obtained from the NCBI GenBank (https://ftp.ncbi.nlm.nih.gov/genomes/) ...
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Language model-guided anticipation and discovery of mammalian metabolites
Training dataset A training dataset of known human metabolites was obtained from the HMDB, the largest and most comprehensive database ...
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Memories of items and their contexts are encoded by separate groups of human brain cells
Research summaries January 14, 2026 Human memory often needs to associate specific items with the situation in which they appear. ...
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Why do some people die from normally harmless germs?
Michael Levine had just started working as a pediatric infectious diseases doctor in London when he received an urgent call ...
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Polyamine-dependent metabolic shielding regulates alternative splicing
Animals Experimental procedures involving the use of mice were carried out following the ethical guidelines established by the Biosafety and ...
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3D-printed low-voltage-driven ciliary hydrogel microactuators
Single-layer microelectrodes fabrication Extended Data Fig. 2 illustrates the fabrication process of single-layer microelectrodes. Below are the step-by-step details: Step 1. ...
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How aging harms the body’s response to raging infections
Staphylococcus aureus Bacteria (artificially colored) were injected into mice to cause a serious condition called sepsis.Credit: Science Source/SPL Genes that ...
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Six steps to protect researchers’ digital security
Academics around the world are coming under increasing criticism. In January 2025, the American Association of Colleges and Universities published ...
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Electrically injected solid-state surface acoustic wave phonon laser
Morgan, D. Surface acoustic wave filters: with applications to electronic communications and signal processing (Academic Press, 2010). Hashimoto, K. Surface ...
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