A model plant study reveals how protein assembly affects the regulation of genes and lacin

Lagini silences the main biological processes, from the time of flowering in plants to preventing the growth of uncontrolled cells that drive cancer in humans.

This basic cellular process includes that genes are turned off, for example, in response to chemical or environmental effects, with changes to cell character without changing the primary genes sequence.

If we can understand the detailed molecular mechanisms that lie behind the laxity of the Lagina, we may be able to raise crops that grow more efficiently and develop treatments that prevent diseases.

Professor Caroline Dean Persians at the John Anas Center has made great steps in this influential biological science.

The previous research conducted by the group highlighted the importance of the presence of a protein PRC2 (Film Polycomb Complex 2) in the FLC floral gene. In plants such as arabidopsis Thaaliana, the lagini lasation for FLC works over the cold winter as a flower brake, allowing the plant to move to flowers in the spring, a process known as drawing.

In a new research Published in Molecular cellThe researchers used the two Arabaidobsis, auraa, to investigate the functional role of the polymerization-a process in which proteins form groups similar to the dynamic chain. Focus on protein – VIN3 and VRN5 – interact with the PRC2 complex and show that the monologue properties of these proteins are necessary in helping to turn off the FLC gene.

These important details add to our understanding of how the lacinalization occurs, and is suitable for an emerging image of protein assembly as a critical topic of genes regulating in plants and animals.

“We make it clear that there is strength in the numbers: when proteins collect together, they help them to stick to the bottled DNA – in this case, the area that contains the gene that must be stopped,” explains the first author of the study, Dr. Anna Schulton.

“By showing how these proteins work together to silence a major flower gene, the search for a new layer of control reveals how plants respond to seasonal changes and provide mechanical visions of genes regulation.”

While this research is related to plants and can be used to genetically adjust the timing of flowers in crops, it has wider effects because the PRC2 is also present in animals and humans.

In humans, the deformations in PRC2 can lead to various diseases, including cancer, nervous degeneration disorders and growth defects.

The study enhances, cooperating with the University of York and MRC LMB in Cambridge, that plants offer a strong model for understanding the principles of Lagin operations that can be applied to all life.