Patrick Mahomes taking on the Tennessee Titans and their decimated secondary could have been one of the best matchups of the year for NFL DFS players to target. Instead, Mahomes went down with a torn ACL last week as the Chiefs also saw their playoff hopes end. What level of confidence can you put in his backup, Gardner Mincio, when he plays against the Giants on Sunday afternoon? Minshew is priced at $4,500 on FanDuel and $6,500 on DraftKings, making him a much cheaper option than other quarterbacks in the NFL DFS player pool like Josh Allen, Dak Prescott and Joe Burrow, but not as cheap as Quinn Ewers, who will start in place of Tua Tagovailoa.
Who should you target at QB, and who are the sleepers in the NFL DFS player pool that can help differentiate your lineups? Before making any NFL DFS picks for Sunday or securing NFL DFS lineups on sites like DraftKings and FanDuel, be sure to: Check out SportsLine’s advanced NFL DFS lineup optimizer.
The DFS Optimizer uses information from the SportsLine Advanced-Data Projection Model and DFS Professional Millionaire Mike McClure to determine the best DFS picks/runs for any slate on betting apps like DraftKings and FanDuel. It simulates every game 10,000 times to help DFS players improve and build winning DraftKings and FanDuel lineups. Optimize, export and input lineups with confidence with injury updates, floor and ceiling player projections, Vegas lines and picks all with one winning tool.
Now, SportsLine’s NFL DFS Optimizer has turned its attention to the 2025 NFL Week 15 schedule for Sunday and just wrapped up its best daily fantasy football lineups. You can only see the perfect lineups at SportsLine.
Top NFL Week 16 DFS picks for Sunday
One of the Optimizer’s top DFS value picks for Sunday is Texans quarterback CJ Stroud at $5,500 on DraftKings and $7,200 on FanDuel. He faces a Raiders team that has allowed opposing quarterbacks to have the eighth-highest rating this season. Stroud is also coming off one of his most complete performances of the season, throwing for 260 yards and three touchdowns with no interceptions and taking just one sack. See who else you can choose here.
You can also bet on Stroud to pass for 227.5 total yards on DraftKings:
The optimizer’s NFL DFS strategy also includes building around Lions receiver Jameson Williams at $6,400 on DraftKings and $6,700 on FanDuel. Williams has a tremendous matchup against a Pittsburgh secondary that has given up the seventh-most yards to opposing receivers this season. Pittsburgh’s defense won’t have starting cornerback James Pierre (calf) and starting edge rusher T.J. Watt (lung) again this week. That should make life even easier on Detroit’s passing game, and Williams is the value play from the unit as he comes in approximately $2,000 cheaper than Amon-Ra St. Brown on both sites. You can see the rest of the optimizer’s NFL DFS picks here.
Bet Williams to go Over 69.5 receiving yards at DraftKings:
How to build Sunday Week 16 NFL DFS lineups
The NFL DFS Optimizer is also targeting multiple undervalued players who could explode for huge numbers on Sunday. Those players could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who they are, and the rest of the optimizer’s NFL DFS picks, at SportsLine.
So what is the optimal NFL DFS lineup for Sunday, and which under-the-radar NFL DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice and stacks, all from an NFL DFS optimizer that simulates every game 10,000 times, and find out.