How development explains the rates of autism in humans

Paper Molecular biology and development It finds that the relatively high rate of autism spectrum disorders is likely to be due to the development of humans in the past. The paper is entitled “A general principle of nervous development that reveals a kind of human hasty neurons that is likely to have a rise in the spread of autism in humans.”

About one in every 31 (3.2 %) of children in the United States were identified with autism spectrum disorder. Globally, the World Health Organization estimates that about one in 100 children suffer from autism.

From an evolutionary perspective, many scientists believe that autism and schizophrenia may be unique to humans. It is very rare to find behaviors associated with disturbances in non -human mainly. In addition, behaviors associated with these disorders generally include cognitive features such as speech and understanding, either unique or more developed in humans.

With the development of single RNA sequence, it has become possible to identify specific types of cells across the brain. When researchers have published more than large -scale data collections, it became clear that the mammal brain contains an amazing set of nerve cells.

In addition, sequence studies have extensively identified wide genetic changes in the unique brain on the homogeneous sane-genetic elements that have not changed much in the development of mammals in general but have evolved rapidly in humans.

While previous investigations found that some types of cells remained more consistent throughout the development than others, the factors that lead these differences in the evolutionary rate are still unknown.

The researchers here recently investigated the nucleic cross -sequence data collections of three distinct areas of mammal brain. They found that the most types of neurons in the outer brain are abundant, L2/3, have evolved exceptionally in human proportions compared to other monkeys.

Surprisingly, this accelerated development was accompanied by dramatic changes in the genes associated with autism, which is likely to be driven by the natural selection of human proportions. The researchers explain that although the results strongly indicate the natural selection of genes associated with autism spectrum disorder, the reason why these benefits give them for human ancestors are unclear.

The answer to this is difficult because we do not know what the features of human perception, the anatomy of the brain, and nerve wires gave human ancestors the advantage of fitness, but researchers here speculate that many of these genes are related to developmental delay, so their development could contribute to the slower brain development in humans compared to the cream.

Moreover, the ability to produce speech and unique understanding of humans is often affected by autism and schizophrenia.

It is possible that the rapid development of genes associated with autism gives the fitness advantage by slowing the brain growth after birth or increasing the ability of the language; Early childhood brain growth time was useful for human development because it led to more complex thinking.

The main author of the newspaper, Alexander, said.